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KMID : 0043320080310030323
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Archives of Pharmacal Research
2008 Volume.31 No. 3 p.323 ~ p.329
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A New Triterpenoid from Panax ginseng Exhibits Cytotoxicity through p53 and the Caspase Signaling Pathway in the HepG2 Cell Line
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Huang Jian
Tang Xiao-Hui
Ikejima Takashi
Sun Xiu-Jia
Wang Xiao-bo
Xi Rong-gang
Wu Li-jun
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Abstract
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A new triterpenoid, 20(R),22,24(S)-dammar-25(26)-ene-,20,22,24-hexanol (1), and three known triterpenoids, -D-glucopyranoside,()-12,20-dihydroxydammar-24-en-3-yl,6-acetate (2), 20(R)-ginsenoside (3), and 20(R)-ginsenoside (4), were isolated from the leaves of Panax ginseng. Their structures were determined by chemical analysis and spectral methods (IR, 1D and 2D NMR, HR-ESI-MS). Compounds 1-4 were exhibited various degrees of cytotoxicity in the human hepatoma cell line, HepG2. Compound 1 had the highest cytotoxic Potency, with an value of 20.1 , by stimulating p53-mediated cell cycle arrest at the G1 to S phase transition, leading to apoptosis via activation of the caspase signaling pathway.
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KEYWORD
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Panax ginseng, Triterpenoid, Cytotoxicity, HepG2, Cell cycle, p53, Caspase
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